Railtown AI Technologies Inc. (CSE:RAIL) Joins the CSE for a Virtual Market Open

The CSE warmly welcomed Railtown AI Technologies Inc. (CSE:RAIL) for a virtual Market Open on December 2, 2021. 

Railtown AI Technologies develops a software-as-a-service artificial intelligence solution that helps software development teams detect, analyze and fix errors quickly in their development projects. Real-time exception monitoring and alerting permits developers, team managers and executives to quickly locate, understand and correct errors in their software development projects, and their root causes, preventing system and application downtimes.

CTO Marwan Haddad, CEO Cory Brandolini, and other members of the amazing Railtown AI Technologies team kicked off the day’s trading at the virtual Market Open. 

For more details about the CSE, including information on other Market Opens, please visit the CSE website or follow us on social media.

Legible Inc. (CSE:READ) Joins the CSE for a Virtual Market Open

The CSE warmly welcomed Legible Inc. (CSE:READ) for a virtual Market Open on December 1, 2021. 

Legible has launched a new digital reading and publishing system, which helps solve key challenges faced by readers, publishers, and authors. Legible is a browser-based, mobile-first, globally distributed publishing and reading platform that allows authors, publishers, and ebook developers the opportunity to create and sell their books in the highest quality multimedia with modern code bases and the full spectrum of HTML.

Founder & CEO Kaleeg Hainsworth and other members of the amazing Legible team kicked off the day’s trading at the virtual Market Open. 

For more details about the CSE, including information on other Market Opens, please visit the CSE website or follow us on social media.

Revitalist Lifestyle and Wellness: On a mission to treat mental health and chronic pain on a global scale with integrated care

An estimated 265 million people worldwide suffer from depression, with the related cost to society – financial and otherwise – almost too great to comprehend. A Stifel GMP research report published in January 2021 indicates that psychedelic-assisted psychotherapy clinics have an addressable market opportunity in the US alone of US$10 billion to $11 billion.

Knoxville, Tennessee-based Revitalist Lifestyle and Wellness (CSE:CALM) operates five ketamine infusion clinics in the United States. The company is dedicated to empowering individuals to achieve improved quality of life through a combination of comprehensive care and future-focused treatments provided by medical professionals, mental health experts and chronic pain specialists.

In a recent interview with Canadian Securities Exchange Magazine, Revitalist Chief Executive Officer Kathryn Walker discussed the company’s growth plans and the advantages of its business model.

How does Revitalist distinguish itself from other publicly traded mental wellness companies? What makes your model better?

Revitalist is the first clinic model to effectively integrate medical and mental health providers working in a team manner with each client. It’s something the medical community has been wanting to do for 30 years, but no one’s really known how to do it. Therapists have started working in medical providers’ offices, but they still don’t work seamlessly on the topic at hand.

The opportunity that we have with psychedelic treatments is that medical providers are making sure the client is safe while the mental health providers are intervening actively during the session, focusing on unfolding the unhealthy conditioning the brain has acquired through many years of ineffective treatments and therapies. We are the first effective model that is being actively covered by insurance, allowing us to expand access to individuals across the country.

What specific roles do psychedelics play in the treatment methods?

At this time, Revitalist primarily provides ketamine infusions. With the psychedelic piece, we have therapists that are trained through the FDA MAPS program. We also have anesthesia providers that have administered every intravenous medication, making them experts in critical care medicine and giving our clients that extra layer of safety and care.

Our anesthesia providers are oftentimes referred to as “pharmacologic physiologists.” In a time where psychedelics are being actively formed in research labs, an excellent person to have on your team is a pharmacologic physiologist. As the pharmacology piece evolves with FDA approval of these exciting medications, the big pharmaceutical companies will want CRNAs (Certified Registered Nurse Anesthetists) as part of their team, and Revitalist will be able to meet that need.

The mental health system is only about 30% effective with its current treatment models. This includes many of the medications that are prescribed, including SSRIs, SNRIs, TCAs and MAOIs. Anesthesia is more than 99% accurate.

What would you say has been Revitalist’s most significant accomplishment thus far?

I think the most significant accomplishment we have right now is in the works, where we are bringing the inpatient experts to the outpatient world. The providers we have with our company are all top line. They know how the current system operates, and they are aware of what should be converted to this system, and what should not.

Revitalist is here to create an entire new model of healthcare that will bridge the old system of health to the new system of psychedelics.

In the hospital sector, when a patient comes to the hospital, we know we have a team on standby and we are going to work together to give that person the best care they deserve. As medicine and insurance companies have evolved, so has our inpatient healthcare system. Now is the time to recreate a healthier structure that is more cost effective in an outpatient environment.

I personally think the mental health and medical system is imploding. The system is off balance, and everyone in and around it can feel that imbalance. We keep seeing more of it every day. Revitalist and the providers who know that system are reshaping a new one, and we are so ready and excited to do so. We’re able to address this issue not only locally and nationally, but also globally as our medical licenses are able to cross lines in over 39 countries.

The healthcare sector needs to recognize that it is in a transition period. It’s like changing homes. They need to leave behind what isn’t necessary and only take what makes sense for the system going forward. Only providers that understand the “old” system and realize the positivity of the “new” will be able to lead the bridged transition. The providers at Revitalist will be that bridge.

What needs to be done to take Revitalist to the next level? Talk about your growth strategy.

We plan on opening 48 clinics in 2021 and 2022 with a goal of having 157 locations in 2025.

What sets us apart is a shared governance with our clinic model. Our recruitment is key, and it makes us stand alone in this space. We have our lead providers, we have corporate personnel that can also act as providers, and we have our own locum providers. This allows us to create and keep consistency amongst every facility we open.

We provide every clinic we open with access to our operations teams, human resources departments, training centres, and marketing team, allowing robust support to everyone involved with our company.  And that upholds a quality of care that is consistent across the board.

Continuity of care is something we want every person that goes into a Revitalist to know and understand. If you are in Maine or in California and you see a Revitalist, you will know what you can expect from us.

Are the clinics you’re acquiring already profitable? What are their sources of revenue?

We’re probably doing a 90-10 split – that is, we are building 90% of the clinics and then acquiring approximately 10%. The space is very fragmented when it comes to psychedelics, and with ketamine clinics a lot of them are part-time clinics that are not making revenue. These are clinics that others seem to be acquiring, but this is a decision we feel would not benefit our company or our investors. Our location specialists analyze data for facility placements to find the biggest bang for our buck. We place our clinics with strong university presence and veteran hospitals, allowing continuation of our base revenue lines.

What do your shareholders have to look forward to in the next 12 months?

We have so many strategic partnerships coming to fruition. One of the biggest services we offer that sets us apart from the others is the fact that we accept federal and commercial insurance. We are also positioned with Veterans Affairs (VA). We have contracts allowing veterans to be directly referred to us under the protocols specific to the individual VA locations.

I think we’ll see insurance companies learn to accept it more. And we do have our own internal insurance team of specialists which, again, sets us apart immensely. We will be able to provide access to this on a cost-saving basis. If you look at what we need to operate, it’s about 10% cost-wise as compared to our competitors. We have so many projects going on behind the scenes, it’s going to be exciting seeing it all unfold.

One of the many reasons we are cost effective is because of the prices we charge. Our average is $275 per infusion, and I know some of our competitors charge on average around $1,200. If you’re charging $1,200, that’s really going to limit a lot of individuals’ access to these services, especially when they’re not accepting insurance. Given that we can accept insurance and our cost is significantly lower, I think you’ll see the need for our services develop much more quickly. For our investors, we’re working on becoming the first comprehensive psychedelic centre in the world.

This story was featured in the Canadian Securities Exchange magazine.

Learn more about Revitalist Lifestyle and Wellness at https://revitalist.com/

Revive Therapeutics: Developing Novel Treatments for TBI, Addiction, and COVID-19

Revive Therapeutics (CSE:RVV) is in the spotlight these days for good reason, thanks to a portfolio of prized intellectual property in the psychedelics field, as well as a COVID-19 drug candidate.

In March of last year, Revive acquired Psilocin Pharma for its psilocybin-based IP and treatments. Psilocin founder Derrick Welsh now spearheads Revive’s psychedelics division.

Revive further boosted its pipeline through an exclusive license with the Puerto Rico Science, Technology and Research Trust to advance medicinal mushroom Ganoderma lucidum compounds to help cancer patients.

On the COVID-19 front, Revive is evaluating rheumatoid arthritis drug Bucillamine as a potential treatment for inflammation caused by COVID-19. 

We recently caught up with Revive Chief Executive Officer Michael Frank to talk about the company’s strategy for building a valuable drug pipeline and patent portfolio.

Revive is working on solutions for quite a varied range of patient needs. Why is the company’s work a compelling story for investors?

Revive has a strong platform in two areas targeting rare disorders and infectious diseases. The FDA has approved a Phase 3 trial for Bucillamine aimed at COVID-19, which is a tremendous milestone for us. We’ve also got a strong portfolio around psychedelics, and we are working with a lot of US universities, so we have two best-of-breed platforms. We’re developing novel psilocybin and cannabidiol therapeutics and have a patent portfolio covering methods and compositions of drugs. 

The Psilocin Pharma acquisition has galvanized Revive’s move into psychedelics. What psilocybin treatments are you moving down the clinical path?

We acquired Psilocin from its founder over a year ago. We took our delivery systems in cannabis and transcended them to psychedelics. Psilocin Pharma has IP covering methods of production of psilocybin formulations, and we want to take it down the clinical path by developing products around breath strips, lozenges, and sprays.

We’re working with US universities on preclinical/clinical studies that aim to channel psilocybin in various formulations and delivery methods to treat mental health, substance use disorders, methamphetamine addiction, and neurological disorders. We’re partnering with the University of Wisconsin to conduct a Phase 1/2 clinical study to evaluate psilocybin in adults with methamphetamine use disorder and traumatic brain injury (TBI)/stroke.

We’re also working with the University of Health Sciences Antigua on our tannin chitosan drug delivery technology to deliver psychedelics in an oral thin film patch in human clinical studies to support regulatory approvals globally. We’ve developed a hydrogel that’s going to be used for dosing patients in Antigua. Revive will be one of the companies to have a psilocybin product that’s going to be taken by patients – in the next four to five months – to treat mental health and substance use disorders.

The University of Wisconsin has done the early stages of our formulation work and now have to move it along the clinical path with partners like LTS. The university has done a lot of work on opioid addiction and other areas, but these are Phase 1/2 clinical trials aimed at methamphetamine addiction and TBI/stroke. Enrollment will continue throughout Q1 2022, and we will have access to IP from the two studies. There’s early data that shows psilocybin could be effective for dealing with addiction as a whole.

What is driving Revive to look at psilocybin as a solution to managing TBI and stroke? 

We have data from our initial trial at the University of Health Sciences National Health Research Institutes. In the mouse model study, we saw favourable results in one group of mice, and the study signalled the neuro-reparative effect of psilocybin. 

The mice were assigned to four groups, which included the control group and the mice with TBI who were given psilocybin. Cognitive function was examined by the Morris water maze test. It found psilocybin, given after injury, improved cognitive function in TBI mice.  

Since the mice with concussions, who had high-dose psilocybin, did really well, we’re using the data to push forward with brain injury studies and an FDA clinical study at the University of Wisconsin-Madison with patient enrollment. It’s early stage, but we’re working with incredible universities to build the science. This is important work because millions of children with hockey, football, and other sports concussions end up with brain fog and a multitude of other symptoms. 

How are your psilocybin oral thin film strip development and psilocybin biosynthesis programs progressing?

The programs are progressing nicely. Our work with LTS Lohmann on oral thin film formulation is a unique opportunity – they are a one-stop shop for us. They are going to take the product, put it through testing, and by the end of it, we’re going to have data to support our claim for a pre-Investigational New Drug (IND) and IND.  

With the North Carolina State University collaboration, Revive is developing a biosynthetic version of psilocybin based on a natural biosynthesis enzymatic platform. It’s been developed by Dr. Gavin Williams at NC State for producing psilocybin efficiently using an engineered enzymatic pathway in E. coli.

Turning E. coli bacteria into a microbial factory for producing chemotherapy drugs has been successful. Vitamins also use E. coli or a yeast model. We’re looking to produce artificial biosynthetic psilocybin using the same E. coli pathway, but it won’t be exactly the same. We’re waiting on the Drug Enforcement Administration to permit us to go to the next step. 

Psilocybin is expensive; there’s limited supply, so companies will need synthetic options. At the end of our synthesis process, we are hoping to be able to provide the active pharmaceutical ingredients (APIs) for our own products. We’ll have a powertrain that can not only supply our own API, but build a great synthesis platform that will lend itself to mental health and addiction.

Let’s conclude with your work regarding Bucillamine as a treatment for lung inflammation in patients with mild-to-moderate COVID-19.

Our double-blind, placebo-controlled Phase 3 clinical trial for Bucillamine for COVID-19 is based on 1,000 patients and up to 50 sites in the US. We are adding viral load testing to support work done by the University of California, San Francisco for a minimum of 300 patients in this 1,000 person study. 

Bucillamine has a well-known safety profile – it’s been prescribed for rheumatoid arthritis in Japan and South Korea for 30 years. We’ve also successfully finished a Phase 2a FDA clinical trial of Bucillamine for gout back in 2015.

In late summer 2020, when we applied for a Phase 2 trial for COVID-19, we were fast-tracked by the FDA and asked to prepare an IND for a Phase 3 confirmatory trial for COVID-19 because of our gout study and the history and safety of Bucillamine.

Learn more about Revive Therapeutics at https://revivethera.com/

Swarmio Media Holdings Inc. (CSE:SWRM) Joins the CSE for a Virtual Market Open

The CSE warmly welcomed Swarmio Media Holdings Inc. (CSE:SWRM) for a virtual Market Open on November 25, 2021. 

Swarmio Media is a gaming and esports technology company that provides solutions purpose-built to support the growth of esports communities, esports teams, game developers, and telecom operators. Their solutions, through their wholly-owned subsidiary, include a proprietary patented “smart edge computing” technology and a gamer engagement and monetization platform.

CEO Vijai Karthigesu and other members of the amazing Swarmio Media team kicked off the day’s trading at the virtual Market Open. 

For more details about the CSE, including information on other Market Opens, please visit the CSE website or follow us on social media.

Canadian Securities Exchange Magazine: The Psychedelics Issue – Now Live!

Welcome to the latest issue of the Canadian Securities Exchange Magazine, your source for in-depth stories of entrepreneurs from a wealth of different industries.

Psychedelics has emerged as a rapidly-evolving industry in the last few years. In this issue of Canadian Securities Exchange Magazine, we’re thrilled to share stories of visionary entrepreneurs in this sector.

We shine a spotlight on five publicly-listed psychedelics companies on the CSE who are looking back to older medicines in order to move forward, and developing innovative treatments designed to achieve better health outcomes for people experiencing mental health conditions, chronic pain, addiction, and more.

The CSE-listed companies featured in this issue include:

Check out the Psychedelics Issue of Canadian Securities Exchange Magazine here:

Anthony Durkacz on Building a Turnaround at FSD Pharma | The CSE Podcast Ep6-S2

CSE’s Barrington Miller is joined by Anthony Durkacz, Interim CEO of FSD Pharma (CSE:HUGE) to discuss the company’s recent history and transition from the cannabis-era to new opportunities in the growing psychedelics space.

Here’s an overview of what Barrington and Anthony discuss in this edition of the “Exchange for Entrepreneurs” podcast:

0:00 – Introducing Anthony Durkacz, Interim CEO of FSD Pharma
5:45 – Working back towards a 1Bn market cap
8:10 – The latest investment in Lucid Psycheceuticals Inc. and treating MS
10:50 – The psychedelics movement
14:13 – Listing on NASDAQ

About FSD Pharma Inc.
FSD Pharma, Inc., is a publicly traded holding company since May 2018.

FSD BioSciences, Inc., a wholly-owned subsidiary, is a specialty biotech pharmaceutical R&D company focused on developing over time multiple applications of its lead compound, FSD201, ultra-micronized palmitoylethanolamide (PEA). Ultra-micro PEA is known to target the CB2 receptors of the endocannabinoid system of the human body and acts by down-regulating the pro-inflammatory cytokines to effectuate an anti-inflammatory response.

The company has successfully completed Phase 1 first-in-human safety and tolerability study for FSD201 and has found the compound to be safe with no serious adverse side effects. This study also validated considerable scientific literature already published in the European Union that claims safety and tolerability of micro-PEA. Ultra-micro PEA is currently beings dispensed in Italy and Spain as a prescription based medical food supplement since 2004.

The company received permission from the Food and Drug Administration (FDA) on June 1, 2020 to submit an Investigational New Drug Application (IND) for the use of FSD201 to treat COVID-19, the disease caused by the SARS-CoV-2 virus.

Severe COVID-19 is characterized by an over-exuberant inflammatory response that may lead to a cytokine storm and ultimately death. The Company is focused on developing FSD201 for its anti-inflammatory properties to avoid the cytokine storm associated with acute lung injury in hospitalized COVID-19 patients.

Learn more about FSD Pharma at FSD Pharma Inc. Subordinate Voting Shares | CSE – Canadian Securities Exchange (thecse.com)

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Tiidal Gaming Group Corp. (CSE:TIDL) Joins the CSE for a Virtual Market Open

The CSE warmly welcomed Tiidal Gaming Group Corp. (CSE:TIDL) for a virtual Market Open on November 17, 2021. 

Tiidal is an esports and gaming platform company focused on owning and operating synergistic businesses in the gaming ecosystem, including its wholly-owned subsidiaries Sportsflare and Lazarus Esports. They focus on media and technology as they believe the key to success is engagement; both their media and technology operations focus on increasing positive fan and consumer engagement and 10-X’ing the esports experience. 

CEO Charles Watson and other members of the amazing Tiidal team kicked off the day’s trading at the virtual Market Open. 

For more details about the CSE, including information on other Market Opens, please visit the CSE website or follow us on social media.

CoinAnalyst Corp. (CSE:COYX) Joins the CSE for a Virtual Market Open

The CSE warmly welcomed CoinAnalyst Corp. (CSE:COYX) for a virtual Market Open on November 1, 2021. 

CoinAnalyst is an AI-based big data analytics platform that enables traders in the cryptocurrency asset sector and other industries to access real-time data from the crypto and initial coin offering (ICO) market. The platform tracks influencers and monitors online social media and websites, and provides sentiment analysis, forecasting, and trading signals on the top 100 cryptocurrencies. 

CEO & Co-Founder Pascal Lauria, COO Andrew Sazama, and other members of the amazing CoinAnalyst team kicked off the day’s trading at the virtual Market Open. 

For more details about the CSE, including information on other Market Opens, please visit the CSE website or follow us on social media.

Li-Metal Corp. (CSE:LIM) Joins the CSE for a Virtual Market Open

The CSE warmly welcomed Li-Metal Corp. (CSE:LIM) for a virtual Market Open on November 15, 2021. 

Li-Metal is a Canadian-based company developing lithium metal anodes and lithium metal production technologies for use in next generation batteries. Their production methods are significantly more sustainable than existing products and offer lighter, more energy dense and safer batteries that are critical to tomorrow’s electric vehicles.

CEO Maciej Jastrzebski and other members of the amazing Li-Metal team kicked off the day’s trading at the virtual Market Open. 

For more details about the CSE, including information on other Market Opens, please visit the CSE website or follow us on social media.